Single-concentration screening
Compare a candidate series in the same assay configuration and identify candidates for confirmation.
Data & readouts
Quantitative outputs designed to compare, prioritize and confirm.
SYGPeD™ structures the readout around controls, a reference condition and quantitative comparison between candidates.
Readouts
Two main formats for two decision steps.
Dose-response
Characterize selected candidates and estimate IC₅₀ when supported by design and quality criteria.
Conceptual illustrations; demonstration charts are not experimental data unless explicitly stated.
Experimental framework
Controls and comparisons defined for each module.
Performance level, readout type and acceptance criteria depend on the target and protocol. Project-specific data are documented within the study.
Reference condition
Establish the module signal in the selected assay configuration.
Candidate comparison
Measure signal change under comparable conditions.
Confirmation
Further characterize selected hits by dose-response or a complementary design.
Modularity evidence
A reference immune-checkpoint module and multiple additional target validations.
PD‑1/PD‑L1 supports the primary immune-checkpoint positioning. HER2, EPO and several cytokine models have also been implemented experimentally to evaluate architecture modularity.
PD‑1 / PD‑L1
Reference immune-checkpoint module.
HER2
Experimental validation of a dedicated module.
EPO
Experimental validation of a dedicated module.
Cytokines
Several models investigated experimentally.
Need a scientific level of detail tailored to your project?
Protocols, experimental conditions and module-specific data can be discussed within an appropriate partner exchange.