Configure
Target, assay conditions, controls, comparators and candidates.
Functional biosensing · R&DMeasure the effect.
Measure the effect.
Prioritize the decision.
SYGPeD™ turns a targeted biological interaction into a quantitative readout to compare, prioritize and confirm research candidates. The platform is primarily focused on immune-checkpoint R&D, with PD‑1/PD‑L1 as its reference module.
Immune checkpointsPD‑1/PD‑L110+ years R&DRUO
SYGPeD™ measurement principle
Same module, two comparable conditions
ConceptualSame module, two comparable conditions
Reference
Target → SYGPeD™ recognition interface
High signal
Same module · two comparable conditions
With candidate
Candidate perturbs target engagement
Lower signal
Target–interface engagement → quantitative signal. Conceptual illustration.
10+ yearsof research and development behind SYG technologies
PD‑1/PD‑L1reference immune-checkpoint module
Multi-targetexperimental validation across PD‑1/PD‑L1, HER2, EPO and cytokine models
RUOplatform and collaborations for research use
Why a functional readout?
Complement binding with a quantitative measure of the effect on the interaction under study.
SYGPeD™ provides a comparative assay-level readout to support candidate selection and organize confirmation steps.
BindingRecognition / affinity
Document candidate interaction with its target.
+
SYGPeD™Effect on the target interaction
Quantitatively compare candidate impact in the assay context.
Experimental workflow
Configure → Measure → Analyze
Measure
Acquire the signal with a readout system compatible with the module.
Analyze
Normalize, compare and confirm by dose-response where appropriate.
* Indicative timing depends on module and protocol.
Experimental decisions
Fast screening followed by quantitative confirmation.
Single-concentration screening
Compare candidate series and prioritize hits for confirmation.
Dose-response
Compare profiles and estimate IC₅₀ when supported by experimental design and quality criteria.
Conceptual illustrations; demonstration charts are not experimental data unless explicitly stated.
Two complementary capabilities
Measure with SYGPeD™. Explore functional discovery with SYGPeP™.
SYGPeD™
Quantitative functional biosensing
Measure candidate effects on a targeted biological interaction.
- Comparative screening
- Dose-response and IC₅₀ when supported by design
- Primary focus on immune checkpoints
- Modularity supported by HER2, EPO and cytokine models
SYGPeP™
Functional discovery & prioritization
Develop programs aimed at introducing a functional experimental criterion earlier in biomolecule prioritization.
- VHHs, DARPins, peptides and additional formats depending on project
- Partner-defined question and success criteria
- Quantitative confirmation with SYGPeD™ where relevant
Applications
Immune checkpoints first, with an architecture adaptable to additional targets.
PD‑1/PD‑L1 is the reference immune-checkpoint module. Experimental validation on HER2, EPO and several cytokine models supports the adaptability of the SYGPeD™ architecture.
Immune checkpoints
Screening and characterization of candidates targeting checkpoint–ligand interactions.
Multi-target validation
HER2, EPO and cytokine models illustrate the ability to configure the architecture around different biological targets.
New modules
New research directions are explored with hospital, academic and industry teams.
Working on a target, assay or candidate series?
A focused pilot can frame feasibility, controls and the experimental decision you need to make.